glp-1 agonists gastrointestinal side effects constipation diarrhea GI Adverse of Glucagon-Like Peptide-1 Receptor GLP-1 Side Effects: 7 Important

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This last point is critical because food and beverages can interfere with the mucosal absorption of semaglutide, significantly reducing bioavailability

What to Expect in Month 2 Peak nausea: Weeks 6-8 worst for most patients, especially mornings Food aversions: Foods you loved suddenly repulsive (especially meat, coffee) Early satiety: Feel full after 3-4 bites, physical discomfort if you push it Fatigue increases: Combination of medication adjustment and reduced calorie intake Bowel unpredictability: Constipation one day, diarrhea the next Mental fog: Some patients report difficulty concentrating Research from the New England Journal of Medicine on incretin therapies shows this peak-and-resolution pattern is universal across GLP-1 and GIP agonists

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PMCID: PMC6073405